Effects of Estrogen in Gender-dependent Fetal Programming of Adult Cardiovascular Dysfunction

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Renal, cardiovascular and metabolic effects of fetal programming.

Disturbed fetal development has long-lasting effects on the offspring, specifically a higher risk of renal, cardiovascular and metabolic disease in adult life as postulated by Barker’s hypothesis. Relevant to renal outcomes of the offspring are maternal factors such as pre-eclampsia, malnutrition, smoking, drugs etc. The main renal abnormalities in the offspring include reduced nephron number a...

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ژورنال

عنوان ژورنال: Current Vascular Pharmacology

سال: 2019

ISSN: 1570-1611

DOI: 10.2174/1570161116666180301142453